KIR2DL4 — Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4

KIR2DL4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

KIR2DL4's module in each cell type

Cell type	Module	Shares the module with
CD8⁺ T cells	Tissue residence Gut residence	AFAP1L2, FAM3C, HTRA1, KRT81, KRT86, NBL1, PLPP1, PTPN6 +1 more	View in SCUBA
Gamma-delta T cells	NK Receptor Expression cytotoxicity	CRACR2B, GFOD1, GPR171, GPR55, GSTM4, KLRC2, KLRC3, MORF4L2 +4 more
Natural Killer cells	NK Checkpoint Receptors Immune regulation	CD7, CD96, CRACR2B, DAPK2, ECH1, ECI2, ISYNA1, MAP4 +5 more	View in SCUBA

About the gene

Synonyms	103AS, 15.212, CD158D
Chromosome	19: 54803610-54814517
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	CD markers, Predicted intracellular proteins, Predicted membrane proteins
Molecular function	Receptor

Function

Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy. May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells. Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent pro-inflammatory response.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.