Lysosomal Autophagy Membrane
Gene co-expression module in Colorectal carcinoma
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
LAMP1 and LAMP2 are definitive lysosomal membrane markers. ATP6AP2 (PRR) is an accessory subunit of the V-ATPase required for lysosomal acidification. TM9SF2 is a lysosomal/endosomal transmembrane protein. TAX1BP1 is a selective autophagy receptor (ubiquitin-binding). STK24 regulates autophagy and apoptosis. ITM2B and CD9 are membrane proteins with endolysosomal trafficking roles. KLF5 and TSC22D1 are transcription factors. CD47 is an antiphagocytic signal. PERP is a p53 apoptosis effector on membranes. The lysosomal core (LAMP1, LAMP2, ATP6AP2, TM9SF2, TAX1BP1) is strong and reinforced by neighbor M60.
Genes
Most correlated modules
- Integrin Adhesion Signaling · correlation 0.83
- ER Quality Control ERAD · correlation 0.80
- Endolysosomal Autophagy · correlation 0.79
- ER Membrane Biogenesis · correlation 0.76
- ER Protein Processing · correlation 0.74
- Lysosomal Proteolysis ECM · correlation 0.73
- Dissociation Stress Response · correlation 0.71
- Epithelial Junctional Cytoskeleton · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.