Colonocyte Differentiation
Gene co-expression module in Colorectal carcinoma
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
CDH17 (liver-intestine cadherin, canonical colonocyte differentiation marker), HEPH (hephaestin, iron oxidase expressed in differentiated intestinal epithelium), CYP3A5 (cytochrome P450 3A5, drug/xenobiotic metabolism — colonocyte function), CES2 (carboxylesterase 2, intestinal drug metabolism), ABCC3 (MRP3, organic anion transporter), TXNIP (thioredoxin-interacting protein, metabolic stress/differentiation), GSN (gelsolin, actin remodeling), DUSP4 (MAPK phosphatase, negative feedback), MGLL (monoglyceride lipase, lipid metabolism), CAMK2N1 (CaMKII inhibitor). This is a colonocyte differentiation/xenobiotic metabolism module reflecting well-differentiated CRC or normal colonocyte-like tumor cells.
Genes
Most correlated modules
- STAT3 Oncogenic Signaling · correlation 0.85
- Lysosomal Proteolysis ECM · correlation 0.81
- Epithelial Junctional Cytoskeleton · correlation 0.80
- Epithelial Cell Adhesion · correlation 0.78
- ECM Invasion Program · correlation 0.77
- Complement Immune Evasion · correlation 0.76
- Growth Arrest Senescence · correlation 0.74
- Tight Junction Integrity · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.