Epithelial Junctional Cytoskeleton
Gene co-expression module in Colorectal carcinoma
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include MYH9 (non-muscle myosin IIA), PLS1 (plastin, actin bundler), FLNB (filamin B), SPTBN1 (spectrin), CTNNA1 (alpha-catenin), DSG2 (desmoglein-2), and surface serine proteases ST14, TMPRSS2, PRSS8. Together these define an epithelial cortical cytoskeleton and cell-cell junction integrity program. CAST (calpastatin) protects cytoskeletal proteins from calpain cleavage. Uniform expression across subsets is consistent with a core epithelial structural program in CRC cells.
Genes
Most correlated modules
- STAT3 Oncogenic Signaling · correlation 0.90
- Epithelial Cell Junctions · correlation 0.88
- Complement Immune Evasion · correlation 0.88
- Epithelial Cell Adhesion · correlation 0.86
- ECM Invasion Program · correlation 0.81
- Colonocyte Differentiation · correlation 0.80
- Integrin Adhesion Signaling · correlation 0.79
- ER Quality Control ERAD · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.