Tight Junction Integrity
Gene co-expression module in Colorectal carcinoma
| Category | Ankiosis & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
CLDN7 (claudin-7, tight junction protein highly expressed in CRC epithelium, regulates paracellular permeability and invasion), SPINT1 (serine protease inhibitor HAI-1, regulates HGF/MET and matriptase, epithelial barrier), TSPAN3 (tetraspanin, membrane organization), AGPAT2 (lysophosphatidic acid acyltransferase, lipid membrane remodeling), EFHD2 (calcium-binding cytoskeletal adaptor). Module reflects epithelial tight junction integrity and membrane organization. Neighbor to invasion modules M8 and M49, representing the intact epithelial barrier state.
Genes
Most correlated modules
- Clathrin-mediated Endocytosis · correlation 0.91
- Growth Arrest Senescence · correlation 0.85
- Epithelial S100/Keratin · correlation 0.84
- Epithelial Cell Adhesion · correlation 0.80
- Endosomal Vesicle Recycling · correlation 0.79
- ECM Invasion Program · correlation 0.77
- Lysosomal Proteolysis ECM · correlation 0.76
- Endolysosomal Autophagy · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.