Lysosomal Proteolysis ECM
Gene co-expression module in Colorectal carcinoma
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
Top hub CTSB (cathepsin B, lysosomal cysteine protease) and PSAP (prosaposin, lysosomal sphingolipid activator) anchor a lysosomal protease program. GRN (granulin) is a lysosomal growth factor/protease regulator. SDC1 (syndecan-1) and CHPF contribute ECM/proteoglycan remodeling. APLP2 participates in vesicular trafficking and endosomal sorting. RABAC1 is a Rab GTPase effector. TIMP1 modulates extracellular proteolysis. Neighboring M73 (lysosomal membrane/autophagy) reinforces the lysosomal identity of this cluster.
Genes
Most correlated modules
- Integrin Adhesion Signaling · correlation 0.81
- Colonocyte Differentiation · correlation 0.81
- Endolysosomal Autophagy · correlation 0.78
- ER Quality Control ERAD · correlation 0.78
- Tight Junction Integrity · correlation 0.76
- ECM Invasion Program · correlation 0.76
- Epithelial Junctional Cytoskeleton · correlation 0.76
- Complement Immune Evasion · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.