Complement Immune Evasion
Gene co-expression module in Colorectal carcinoma
| Category | Immune evasion |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 8 genes have a known function matching the annotation |
Why this annotation
CD59 (protectin, GPI-anchored complement regulatory protein that inhibits MAC assembly — classic immune evasion in cancer), TMBIM1 (transmembrane BAX inhibitor-1, anti-apoptotic), GPRC5A (retinoic acid-inducible GPCR, expressed in colon epithelium, implicated in tumor suppression/oncogenesis), EMP1 (epithelial membrane protein-1, regulates apoptosis), ANXA11 (annexin XI, calcium-dependent membrane binding), LMO7 (LIM domain only-7, epithelial cytoskeletal), PTTG1IP (pituitary tumor-transforming gene 1 interacting protein, regulates cell cycle/securin). CD59-mediated complement evasion is the strongest functional anchor, supported by anti-apoptotic TMBIM1.
Genes
Most correlated modules
- ECM Invasion Program · correlation 0.91
- Epithelial Junctional Cytoskeleton · correlation 0.88
- STAT3 Oncogenic Signaling · correlation 0.84
- Growth Arrest Senescence · correlation 0.83
- Epithelial Cell Junctions · correlation 0.80
- Integrin Adhesion Signaling · correlation 0.78
- Epithelial Cell Adhesion · correlation 0.78
- Colonocyte Differentiation · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.