Actin Cytoskeleton Regulation
Gene co-expression module in Colorectal carcinoma
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes ARPC5L (Arp2/3 actin nucleation complex) and PPP4C (PP4 phosphatase, actin/cytoskeletal regulation) and RHOA (Rho GTPase master cytoskeletal regulator) define an actin cytoskeletal program. UBE2D3 and STUB1 add ubiquitin-proteasome quality control, and AP2M1 links to clathrin-mediated endocytosis. Moderate coherence and several weak members indicate a mixed module. Neighborhood overlap with M23 (ARPC5/proteasome) confirms shared cytoskeletal-proteostasis co-expression axis.
Genes
Most correlated modules
- ER-Golgi Trafficking · correlation 0.87
- ER Protein Processing · correlation 0.87
- Mitochondrial OXPHOS · correlation 0.86
- Housekeeping Proteostasis · correlation 0.85
- Oxidative Phosphorylation ETC · correlation 0.84
- Proteasome Ubiquitin Degradation · correlation 0.84
- ER Protein Processing · correlation 0.83
- Ubiquitin-Proteasome System · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.