hnRNP RNA Processing
Gene co-expression module in Colorectal carcinoma
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
HNRNPC, HNRNPF, HNRNPK are major heterogeneous nuclear ribonucleoproteins central to pre-mRNA processing, splicing, and export. MTHFD2 and SHMT2 are mitochondrial one-carbon/folate metabolism enzymes that support nucleotide biosynthesis — co-regulated with RNA-processing demands during proliferation. OLA1 (GTPase, ribosome quality control) and LRRC59 (ribosome receptor) support translation. GDI2 is a GDP-dissociation inhibitor for Rab GTPases. The dominant and coherent signature is hnRNP-mediated RNA processing, with metabolic support from one-carbon metabolism. Uniform expression and strong coherence confirm housekeeping RNA processing.
Genes
Most correlated modules
- TRiC Chaperonin Complex · correlation 0.91
- TRiC/CCT Core Complex · correlation 0.90
- Proteasome Degradation · correlation 0.90
- RNA-protein Transport · correlation 0.89
- Nuclear Assembly · correlation 0.88
- Mitochondrial Assembly · correlation 0.87
- Chromatin & DNA Repair · correlation 0.87
- Housekeeping Mixed · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.