Ubiquitin-Proteasome System
Gene co-expression module in Colorectal carcinoma
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
This moderate-coherence module combines 19S proteasome regulatory subunits (PSMD1, PSMD2), a neddylation E2 enzyme (UBE2M), actin-related protein (ARPC5), a Rho-family GTPase effector-adjacent phosphatase (PTP4A2), ARF1 (vesicular trafficking), and RTN3 (ER membrane). The co-expression of proteasome and cytoskeletal elements reflects a shared housekeeping proteostasis/cytoskeletal maintenance program, consistent with its neighbor M71 which also contains proteasome and Arp2/3 components.
Genes
Most correlated modules
- ER Protein Processing · correlation 0.87
- RNA-protein Transport · correlation 0.86
- ER Quality Control ERAD · correlation 0.84
- Post-transcriptional Regulation · correlation 0.83
- Actin Cytoskeleton Regulation · correlation 0.82
- ER-Golgi Trafficking · correlation 0.81
- ER-Golgi Membrane Maintenance · correlation 0.80
- Chromatin & DNA Repair · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.