RNA-protein Transport
Gene co-expression module in Colorectal carcinoma
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes EIF5 (translation initiation factor), KPNB1 (importin beta, nuclear import), YY1 (transcription factor), RBM17 (splicing factor), HNRNPR, HNRNPD (heterogeneous nuclear ribonucleoproteins), KHDRBS1 (RNA-binding), PAPOLA (poly-A polymerase), and YBX3 (Y-box binding protein) collectively point to a broad RNA processing and nucleocytoplasmic transport program. XRCC5 (Ku80, DNA repair) and PPM1G (phosphatase involved in splicing) are consistent members. HSP90AA1 is weakly associated. The module is uniformly expressed with no cell-type enrichment, consistent with a housekeeping-level RNA processing/transport program. Neighbor modules M81 and M24 reinforce the RNA-binding/chromatin theme.
Genes
Most correlated modules
- Pre-mRNA Splicing · correlation 0.93
- Chromatin & DNA Repair · correlation 0.91
- hnRNP RNA Processing · correlation 0.89
- Post-transcriptional Regulation · correlation 0.89
- Chromatin-coupled Splicing · correlation 0.88
- TRiC/CCT Core Complex · correlation 0.87
- Ubiquitin-Proteasome System · correlation 0.86
- Ribosome Biogenesis · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.