Pre-mRNA Splicing
Gene co-expression module in Colorectal carcinoma
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 15 genes have a known function matching the annotation |
Why this annotation
HNRNPA3, HNRNPM, HNRNPA2B1, HNRNPDL (heterogeneous nuclear ribonucleoproteins), SRSF7, SRSF2, TRA2B (serine/arginine-rich splicing factors), SYNCRIP (RNA-binding), SFPQ (splicing/paraspeckle), LBR (nuclear lamina/RNA processing), PARP1 (DNA repair/RNA metabolism), NUCKS1 (chromatin regulator), PSMD14 (proteasome), STIP1 (HSP co-chaperone). Core coherence and multiple HNRNP and SRSF family members make this clearly an mRNA splicing module. Neighbor modules M17 and M81 are also RNA/chromatin processing modules, reinforcing this classification.
Genes
Most correlated modules
- RNA-protein Transport · correlation 0.93
- Chromatin & DNA Repair · correlation 0.91
- Ribosome Biogenesis · correlation 0.88
- Chromatin-coupled Splicing · correlation 0.88
- G2/M Transition · correlation 0.86
- Post-transcriptional Regulation · correlation 0.85
- TRiC Chaperonin Complex · correlation 0.84
- hnRNP RNA Processing · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.