Post-transcriptional Regulation
Gene co-expression module in Colorectal carcinoma
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
GSPT1 (eRF3, translation termination), EIF4G2 (translation initiation), RNPS1 (RNA splicing/EJC), HDGF (hepatoma-derived growth factor, chromatin/transcription), BRD7 (bromodomain, chromatin remodeling), UBE2I (SUMO E2 conjugating enzyme), PSMD7 (proteasome), DEK (chromatin/RNA processing oncogene), MAZ (transcription factor), NOL7 (nucleolar), KIF5B (kinesin motor), VPS35 (retromer complex). This module mixes translation termination, RNA processing, chromatin regulation, and SUMOylation. The neighborhood (M17, M24, M64) supports a housekeeping RNA/protein biogenesis context. The most coherent shared theme is post-transcriptional gene regulation and protein homeostasis.
Genes
Most correlated modules
- RNA-protein Transport · correlation 0.89
- Pre-mRNA Splicing · correlation 0.85
- Chromatin-coupled Splicing · correlation 0.85
- Chromatin & DNA Repair · correlation 0.85
- Ribosome Biogenesis · correlation 0.84
- Ubiquitin-Proteasome System · correlation 0.83
- Mitoribosome Biogenesis · correlation 0.80
- ER Protein Processing · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.