Chromatin & DNA Repair
Gene co-expression module in Colorectal carcinoma
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
XRCC6 (Ku70, DNA double-strand break repair), SMC1A and SMC3 (cohesin complex, chromosomal organization), ALYREF (mRNA export adaptor), SNRPD3 (snRNP, spliceosome), ANP32A (chromatin regulator), HNRNPAB (RNA binding), TMPO (lamina-associated protein, nuclear envelope), FKBP4 (nuclear receptor co-chaperone), PHB2 (prohibitin, chromatin/mitochondria). This module strongly reflects nuclear chromatin organization, DNA repair, and RNA export — a DNA/chromatin regulatory program. Neighbor context (M17, M24) supports nuclear RNA-chromatin housekeeping neighborhood.
Genes
Most correlated modules
- Pre-mRNA Splicing · correlation 0.91
- RNA-protein Transport · correlation 0.91
- hnRNP RNA Processing · correlation 0.87
- G2/M Transition · correlation 0.86
- Post-transcriptional Regulation · correlation 0.85
- TRiC Chaperonin Complex · correlation 0.85
- Ribosome Biogenesis · correlation 0.83
- Nucleotide Biosynthesis · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.