TRiC/CCT Core Complex
Gene co-expression module in Colorectal carcinoma
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
CCT4, CCT2, CCT5, TCP1 are all core subunits of the TRiC/CCT chaperonin complex, which folds actin, tubulin, and other essential proteins. HSPD1 (HSP60, mitochondrial chaperone) and EIF3M (translation initiation factor 3 subunit M) are also involved in protein folding and translation. MRPL3 (mitochondrial ribosomal protein L3) and TOMM20 (translocase of the outer mitochondrial membrane 20) link to mitochondrial protein import. STRAP (serine-threonine kinase receptor-associated protein) participates in spliceosome and translation complexes. The module is core-coherent with very high expression and uniform detection, strongly consistent with a fundamental chaperonin complex housekeeping program. Neighbor context: M22 contains CCT3, CCT8, and PFDN2, confirming that this batch of modules collectively represents the TRiC chaperonin machinery. M58 represents the core CCT ring subunits while M22 represents the prefoldin loading arm.
Genes
Most correlated modules
- TRiC Chaperonin Complex · correlation 0.92
- Proteasome Degradation · correlation 0.91
- hnRNP RNA Processing · correlation 0.90
- Mitochondrial Ribosome · correlation 0.90
- Housekeeping Proteostasis · correlation 0.88
- pre-mRNA Splicing · correlation 0.88
- Chromatin-coupled Splicing · correlation 0.88
- RNA-protein Transport · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.