Chromatin-coupled Splicing
Gene co-expression module in Colorectal carcinoma
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
RBMX (RNA-binding motif protein X-linked, splicing), CBX3 (HP1 gamma, heterochromatin), BZW2 (basic leucine zipper and W2 domain, translation), DKC1 (dyskerin, pseudouridylation/rRNA/telomerase), SRPK1 (SR protein kinase, splicing regulation), NONO (paraspeckle/RNA processing), HDAC2 (histone deacetylase, chromatin), CCT6A (chaperonin complex). This module integrates RNA splicing regulation (RBMX, SRPK1, NONO), heterochromatin (CBX3, HDAC2), and RNA modification (DKC1). Core coherence and the mix of chromatin and RNA processing regulators fits a chromatin-coupled RNA processing program. In the context of neighboring modules (M17, M24), this is part of the same RNA/chromatin housekeeping neighborhood.
Genes
Most correlated modules
- TRiC/CCT Core Complex · correlation 0.88
- RNA-protein Transport · correlation 0.88
- Pre-mRNA Splicing · correlation 0.88
- Ribosome Biogenesis · correlation 0.86
- Post-transcriptional Regulation · correlation 0.85
- Chromatin & DNA Repair · correlation 0.83
- ER Membrane Biogenesis · correlation 0.80
- ER Protein Processing · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.