Nucleotide Biosynthesis
Gene co-expression module in Colorectal carcinoma
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes: RPA3 (replication protein A subunit, DNA replication/repair), TFDP1 (DP-1, E2F dimerization partner, cell cycle transcription), GGCT (gamma-glutamyl cyclotransferase, glutathione metabolism), NUDT1 (MTH1, nucleotide pool sanitization, prevents incorporation of oxidized nucleotides), CYCS (cytochrome c, electron transport/apoptosis), PRPS2 (phosphoribosyl pyrophosphate synthetase 2, purine/pyrimidine synthesis), RBBP7 (retinoblastoma binding protein 7, chromatin/histone assembly), HPRT1 (hypoxanthine phosphoribosyltransferase, purine salvage), PPIA (peptidyl-prolyl isomerase A, chaperone), SLBP (stem-loop binding protein, histone mRNA processing), CCDC34. The dominant theme is nucleotide metabolism and DNA replication-associated activities (RPA3, NUDT1, PRPS2, HPRT1, SLBP, TFDP1, RBBP7). TFDP1 and SLBP link this to S-phase/cell cycle. This module represents nucleotide biosynthesis and DNA replication support, consistent with proliferating tumor cells.
Genes
Most correlated modules
- pre-mRNA Splicing · correlation 0.89
- Mitochondrial Assembly · correlation 0.88
- Mitochondrial Ribosome · correlation 0.87
- G2/M Transition · correlation 0.87
- Nuclear Assembly · correlation 0.86
- Mitochondrial Ribosome · correlation 0.86
- Mitotic Spindle · correlation 0.84
- Proteasome Degradation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.