OxPhos & Mito Import
Gene co-expression module in Colorectal carcinoma
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes: GADD45GIP1 (GADD45 gamma interacting protein 1, mitochondrial ribosome assembly), NDUFS8 (NADH:ubiquinone oxidoreductase Fe-S subunit 8, complex I), ECHS1 (enoyl-CoA hydratase, mitochondrial fatty acid oxidation), MRPL23, MRPL12 (mitochondrial large ribosomal subunit proteins), TIMM13, TIMM10 (translocase of inner mitochondrial membrane), PRDX3, PRDX2 (peroxiredoxins, mitochondrial ROS scavenging), CISD3 (CDGSH iron-sulfur domain, mitochondrial), NDUFS6 (complex I subunit), CYC1 (cytochrome c1, complex III), LDHB (lactate dehydrogenase B), FABP5 (fatty acid binding protein 5), AURKAIP1 (AURKA interacting protein 1, mitochondrial ribosome), DNPH1. This is a strong mitochondrial module encompassing OxPhos (NDUFS8, NDUFS6, CYC1), fatty acid oxidation (ECHS1), mitochondrial import (TIMM13, TIMM10), mitochondrial ribosome (MRPL23, MRPL12, GADD45GIP1, AURKAIP1), and ROS defense (PRDX3, PRDX2). LDHB and FABP5 are slightly peripheral. Consistent with all neighboring modules in this mitochondrial-housekeeping batch.
Genes
Most correlated modules
- Mitochondrial Assembly · correlation 0.91
- Mitochondrial Ribosome · correlation 0.89
- Core Cellular Machinery · correlation 0.89
- Housekeeping Mixed · correlation 0.89
- RNA Processing & Biogenesis · correlation 0.88
- Mitochondrial Ribosome · correlation 0.87
- Oxidative Phosphorylation ETC · correlation 0.85
- Mitoribosome Biogenesis · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.