RNA Processing & Biogenesis
Gene co-expression module in Colorectal carcinoma
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes: SNRPD1 (Sm snRNP D1, core spliceosomal), IMPDH2 (inosine monophosphate dehydrogenase 2, GTP biosynthesis, highly expressed in proliferating cells), PTMA (prothymosin alpha, chromatin remodeling/nuclear), C1QBP (complement component 1 Q binding protein, mitochondrial ribosome assembly/RNA processing), NPM1 (nucleophosmin, ribosome biogenesis/nucleolar), HNRNPA1 (RNA splicing/processing), ERH (enhancer of rudimentary homolog, pyrimidine metabolism/splicing), NPM3 (nucleoplasmin 3, ribosome biogenesis), YBX1 (Y-box binding protein, mRNA processing), APEX1 (apurinic/apyrimidinic endonuclease 1, DNA repair), RANBP1 (Ran GTPase binding, nuclear transport). The collective signature points to RNA processing and ribosome biogenesis (NPM1, NPM3, SNRPD1, HNRNPA1, ERH, YBX1, C1QBP) with proliferation-associated nucleotide synthesis (IMPDH2). Highest mean expression (1.863) and pct positive (74.6%) in this batch, consistent with housekeeping RNA processing.
Genes
Most correlated modules
- Mitochondrial Ribosome · correlation 0.93
- pre-mRNA Splicing · correlation 0.92
- Core Cellular Machinery · correlation 0.91
- Housekeeping Mixed · correlation 0.89
- Nuclear Assembly · correlation 0.88
- OxPhos & Mito Import · correlation 0.88
- Mitochondrial Assembly · correlation 0.88
- eIF3 Translation Initiation · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.