Mitochondrial Ribosome
Gene co-expression module in Colorectal carcinoma
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
Core hub genes: MRPL11, MRPL4 (mitochondrial large ribosomal subunit proteins), NHP2 (H/ACA snoRNP, ribosome biogenesis), NME1 (nucleoside diphosphate kinase, nucleotide metabolism), EBNA1BP2 (ribosome biogenesis factor), CCT7 (chaperonin complex subunit, protein folding), HSD17B10 (mitochondrial 17-beta hydroxysteroid dehydrogenase, also RNA helicase in mitochondria), PRMT1 (protein arginine methyltransferase), LSM7 (spliceosomal Sm-like protein). The module is tightly coherent ('core') and the dominant theme is mitochondrial ribosome (MRPL11, MRPL4, HSD17B10) combined with ribosome biogenesis (NHP2, EBNA1BP2). Given the neighboring mitochondrial modules, this is best classified as mitochondrial ribosome biogenesis.
Genes
Most correlated modules
- RNA Processing & Biogenesis · correlation 0.93
- pre-mRNA Splicing · correlation 0.92
- Housekeeping Mixed · correlation 0.91
- Nuclear Assembly · correlation 0.90
- Mitoribosome Biogenesis · correlation 0.90
- TRiC/CCT Core Complex · correlation 0.90
- Mitochondrial Assembly · correlation 0.89
- Mitochondrial Ribosome · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.