Core Cellular Machinery
Gene co-expression module in Colorectal carcinoma
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include TOMM22 (mitochondrial outer membrane translocase), PSMB5 (proteasome subunit), POLR2F (RNA polymerase II subunit), SNU13/SF3B5 (spliceosomal components), NEDD8 (neddylation/ubiquitin-like), UQCRFS1 (mitochondrial complex III), and MRPL52 (mitochondrial ribosome). This is a mixed housekeeping module combining core cellular machinery: protein import (TOMM22), proteasome (PSMB5), transcription (POLR2F), splicing (SNU13, SF3B5), neddylation (NEDD8), and mitochondrial function (UQCRFS1, MRPL52). Uniform expression across all subsets with moderate-high pct positive confirms housekeeping identity. In the context of neighboring modules (M78, M34, M27, M2) which are also housekeeping/mitochondrial, this batch represents core cellular maintenance programs. The module is too heterogeneous to assign a single precise pathway, but the dominant theme across hub genes is general cellular machinery.
Genes
Most correlated modules
- Mitochondrial Assembly · correlation 0.92
- RNA Processing & Biogenesis · correlation 0.91
- Proteasome Ubiquitin Degradation · correlation 0.91
- OxPhos & Mito Import · correlation 0.89
- Housekeeping Mixed · correlation 0.89
- Nuclear Assembly · correlation 0.88
- Mitochondrial Ribosome · correlation 0.88
- Mitochondrial OXPHOS · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.