Mitochondrial Assembly
Gene co-expression module in Colorectal carcinoma
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
Key genes include GLRX5 (glutaredoxin 5, iron-sulfur cluster assembly), VDAC3 (mitochondrial outer membrane voltage-dependent anion channel), SLC25A39 (mitochondrial folate transporter), NDUFC2 (NADH:ubiquinone oxidoreductase subunit, complex I), UQCC2 (ubiquinol-cytochrome c reductase complex assembly factor), PYURF (mitochondrial UMP synthase chaperone). SIVA1 is a pro-apoptotic protein, TXNL4A is a spliceosomal thioredoxin-like protein, SNRNP25 is a spliceosomal component, NUDCD2 is a cochaperone. The dominant theme is mitochondrial function and assembly (GLRX5, VDAC3, SLC25A39, NDUFC2, UQCC2, PYURF) with some splicing components co-expressed. Given the neighbor context of mitochondrial modules (M85, M2, M34), this module best represents mitochondrial biogenesis/assembly housekeeping.
Genes
Most correlated modules
- Mitochondrial Ribosome · correlation 0.93
- Housekeeping Mixed · correlation 0.92
- Core Cellular Machinery · correlation 0.92
- OxPhos & Mito Import · correlation 0.91
- pre-mRNA Splicing · correlation 0.90
- Mitochondrial Ribosome · correlation 0.89
- Nuclear Assembly · correlation 0.89
- Nucleotide Biosynthesis · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.