Mitoribosome Biogenesis
Gene co-expression module in Colorectal carcinoma
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes MRPS34 and MRPS12 are mitochondrial ribosomal proteins (small subunit), MRPL36 is a mitochondrial ribosomal protein (large subunit), TUFM is mitochondrial elongation factor Tu (required for mitochondrial translation), TOMM40 is the translocase of the outer mitochondrial membrane 40 (protein import), FBL (fibrillarin, rRNA methylation in nucleolus), RSL1D1 (ribosomal L1 domain containing 1, nucleolar), DCTPP1 (dCTP pyrophosphatase, nucleotide metabolism), TKT (transketolase, pentose phosphate pathway), PDCD6 (apoptosis-linked), HMGN1 (chromatin). The dominant program is mitochondrial translation/ribosome assembly, with nucleolar components suggesting co-regulation of cytoplasmic and mitochondrial ribosome biogenesis. Uniform expression across all subsets with strong coherence confirms a constitutive housekeeping program. Neighbor context: M9 contains NDUFAB1/MRPL18, M58 contains MRPL3/TOMM20 - this neighborhood collectively covers mitochondrial biogenesis (import, translation, OXPHOS assembly), with M72 specifically enriched in mitoribosome subunits and mitochondrial translational elongation.
Genes
Most correlated modules
- Mitochondrial Ribosome · correlation 0.90
- TRiC Chaperonin Complex · correlation 0.87
- Mitochondrial OXPHOS · correlation 0.86
- Mitochondrial Ribosome · correlation 0.85
- TRiC/CCT Core Complex · correlation 0.84
- Housekeeping Proteostasis · correlation 0.84
- OxPhos & Mito Import · correlation 0.83
- eIF3 Translation Initiation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.