Housekeeping Mixed
Gene co-expression module in Colorectal carcinoma
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
EIF3I drives translation initiation; LSM4 participates in spliceosomal U snRNP assembly; MRPL20, MRPS15, MRPL21 are mitoribosomal subunits; PSMB2 is a proteasome beta subunit; MDH2 is a TCA cycle enzyme; PARK7 is a multifunctional housekeeping protein (chaperone/oxidoreductase); ZNF593 is a constitutive RNA-binding zinc finger. The module blends translation, splicing, mitochondrial, and proteasome components — all core housekeeping programs expressed uniformly. Core coherence and uniform expression confirm constitutive housekeeping.
Genes
Most correlated modules
- Mitochondrial Assembly · correlation 0.92
- pre-mRNA Splicing · correlation 0.91
- Nuclear Assembly · correlation 0.91
- Mitochondrial Ribosome · correlation 0.91
- Mitochondrial OXPHOS · correlation 0.90
- Mitochondrial Ribosome · correlation 0.90
- Proteasome Degradation · correlation 0.90
- OxPhos & Mito Import · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.