TRiC Chaperonin Complex
Gene co-expression module in Colorectal carcinoma
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes CACYBP (calcyclin binding protein, involved in protein degradation and chaperone activity), CCT3 and CCT8 (chaperonin containing TCP1 subunit members), PFDN2 (prefoldin subunit 2, co-chaperone), NUDC (nuclear distribution protein, involved in protein folding), ILF2 (RNA binding/stress granule), SERBP1 (RNA binding, translation regulation), and RBM8A (exon junction complex, mRNA surveillance) collectively point to a protein folding and proteostasis program. CCT3/CCT8 are canonical TRiC/CCT chaperonin complex members. PFDN2 is a prefoldin that delivers unfolded proteins to TRiC. CACYBP links calcium signaling to protein degradation via the ubiquitin pathway. The module is uniformly expressed across all subsets with strong coherence, suggesting a housekeeping chaperone/proteostasis program rather than a cell-type specific response. Neighbor context: M58 also contains CCT subunits (CCT2, CCT4, CCT5, TCP1), strongly confirming that both modules represent the TRiC chaperonin complex program. M22 captures the prefoldin/CCT loading arm while M58 captures the core CCT ring itself.
Genes
Most correlated modules
- TRiC/CCT Core Complex · correlation 0.92
- hnRNP RNA Processing · correlation 0.91
- Nuclear Assembly · correlation 0.90
- Proteasome Degradation · correlation 0.89
- pre-mRNA Splicing · correlation 0.88
- Mitochondrial OXPHOS · correlation 0.88
- Mitochondrial Ribosome · correlation 0.87
- Housekeeping Mixed · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.