Mitochondrial OXPHOS
Gene co-expression module in Colorectal carcinoma
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes MTCH2 (mitochondrial carrier homolog 2, regulates mitochondrial apoptosis and metabolism), MRPL18 (mitochondrial ribosomal protein L18), NDUFAB1 (NADH:ubiquinone oxidoreductase subunit AB1, Complex I), NDUFB5 (NADH:ubiquinone oxidoreductase subunit B5, Complex I), SUCLG1 (succinate-CoA ligase alpha subunit, TCA cycle), UQCRC2 (ubiquinol-cytochrome c reductase core protein 2, Complex III), SDHB (succinate dehydrogenase subunit B, Complex II/TCA), ACP1 (acid phosphatase), LSM2 (RNA splicing), FAM162A (mitochondria, hypoxia-induced), PSMA5 (proteasome subunit). The majority of hub genes are mitochondrial respiratory chain and TCA cycle components. Uniform expression across subsets with strong coherence indicates a housekeeping mitochondrial oxidative phosphorylation program. Neighbor context: M58 contains TOMM20, M72 contains TOMM40 and mitoribosome subunits, confirming this network neighborhood is enriched in mitochondrial programs. M9 specifically captures OXPHOS/TCA components.
Genes
Most correlated modules
- Housekeeping Proteostasis · correlation 0.94
- Nuclear Assembly · correlation 0.92
- Housekeeping Mixed · correlation 0.90
- Proteasome Degradation · correlation 0.90
- TRiC Chaperonin Complex · correlation 0.88
- Core Cellular Machinery · correlation 0.87
- Mitochondrial Ribosome · correlation 0.87
- Mitochondrial Assembly · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.