Nuclear Assembly
Gene co-expression module in Colorectal carcinoma
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
ANP32B and BANF1 are nuclear envelope/chromatin organization proteins involved in nuclear assembly after mitosis; SNRPB is a spliceosomal Sm protein; PSMA2 is a proteasome alpha subunit; NDUFB6 and STOML2 are mitochondrial inner membrane/Complex I components; CLTA is constitutive clathrin; HSPA8 is the constitutive HSC70 chaperone. The module combines nuclear chromatin organization (ANP32B, BANF1) with general housekeeping (splicing, proteasome, chaperone). The strongest distinguishing theme relative to neighbors is nuclear/chromatin assembly. Strong coherence with uniform expression supports constitutive housekeeping.
Genes
Most correlated modules
- pre-mRNA Splicing · correlation 0.92
- Mitochondrial OXPHOS · correlation 0.92
- Housekeeping Mixed · correlation 0.91
- Mitochondrial Ribosome · correlation 0.90
- Housekeeping Proteostasis · correlation 0.90
- Mitochondrial Ribosome · correlation 0.90
- Proteasome Degradation · correlation 0.90
- TRiC Chaperonin Complex · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.