ER Quality Control ERAD
Gene co-expression module in Colorectal carcinoma
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
CANX (calnexin, ER lectin chaperone) and TRAM1 (translocon-associated membrane protein) directly link this module to M70's ER folding program. ATP2A2/SERCA2 maintains ER Ca²⁺ homeostasis critical for chaperone function. UBXN4 is a UBX domain protein involved in ER-associated degradation (ERAD). CSNK1A1 (CK1α) and YWHAZ (14-3-3ζ) are signaling scaffold proteins. PCBP1/PCBP2 are RNA-binding proteins with roles in ER mRNA localization. MAL2 and TM9SF3 are membrane trafficking proteins. The module blends ER quality control (ERAD) with associated signaling, explaining its moderate coherence.
Genes
Most correlated modules
- Integrin Adhesion Signaling · correlation 0.88
- Ubiquitin-Proteasome System · correlation 0.84
- ER Protein Folding UPR · correlation 0.82
- Lysosomal Autophagy Membrane · correlation 0.80
- Epithelial Junctional Cytoskeleton · correlation 0.79
- Dissociation Stress Response · correlation 0.78
- Lysosomal Proteolysis ECM · correlation 0.78
- Epithelial Cell Junctions · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.