Integrin Adhesion Signaling
Gene co-expression module in Colorectal carcinoma
| Category | Ankiosis & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
ITGB1 (integrin β1) is the dominant hub with strong core membership, linking cells to ECM. CAP1 (cyclase-associated protein) regulates actin dynamics downstream of integrin signaling. TPM4 (tropomyosin 4) stabilizes actin filaments. RTN4 (reticulon-4/Nogo) modulates membrane curvature and integrin recycling. PPP1CB (PP1β) dephosphorylates cytoskeletal targets. SLC2A1/GLUT1 and ABHD2 add a lipid/metabolic dimension. CTSZ (cathepsin Z) is a lysosomal protease. The module primarily reflects integrin-actin cytoskeletal anchoring, consistent with adhesion programs in CRC epithelial cells.
Genes
Most correlated modules
- ER Quality Control ERAD · correlation 0.88
- Lysosomal Autophagy Membrane · correlation 0.83
- Lysosomal Proteolysis ECM · correlation 0.81
- Epithelial Junctional Cytoskeleton · correlation 0.79
- Complement Immune Evasion · correlation 0.78
- Ubiquitin-Proteasome System · correlation 0.78
- Epithelial Cell Junctions · correlation 0.77
- ER Protein Folding UPR · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.