Epithelial Cell Junctions
Gene co-expression module in Colorectal carcinoma
| Category | Ankiosis & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes JUP (plakoglobin), CDH1 (E-cadherin), DSP (desmoplakin), CTNND1 (p120-catenin), and ACTN4 are all core components of epithelial cell-cell adhesion structures including desmosomes and adherens junctions. RAB11FIP1 (endosomal recycling of junctional proteins), POF1B (non-muscle actin binding at junctions), and SDC4 (syndecan-4, cell-matrix/cell-cell) support an epithelial adhesion program. Module is core coherence, uniform expression consistent with epithelial identity maintenance in CRC cells.
Genes
Most correlated modules
- Epithelial Junctional Cytoskeleton · correlation 0.88
- Hypoxia Response · correlation 0.86
- STAT3 Oncogenic Signaling · correlation 0.80
- Complement Immune Evasion · correlation 0.80
- Integrin Adhesion Signaling · correlation 0.77
- ER Quality Control ERAD · correlation 0.77
- AP-1 IEG Activation · correlation 0.75
- Colonocyte Differentiation · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.