Dissociation Stress Response
Gene co-expression module in Colorectal carcinoma
| Category | Technical artifact |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 12 genes have a known function matching the annotation |
Why this annotation
ATF3 (stress-induced TF), DUSP1 (stress-responsive MAPK phosphatase), PPP1R15A/GADD34 (integrated stress response, PERK pathway), DNAJB1 and HSPA1B (heat shock chaperones), KLF4 and KLF6 (immediate-early KLF factors), TRIB1 and TOB1 (anti-proliferative stress responders), RHOB (RhoB, upregulated by stress and DNA damage), UBC (ubiquitin, stress-induced). This is a canonical dissociation/cellular stress response module, commonly elevated as a technical artifact during single-cell tissue dissociation. Uniform expression supports a non-cell-type-specific stress program.
Genes
Most correlated modules
- AP-1 IEG Activation · correlation 0.85
- ER Quality Control ERAD · correlation 0.78
- Epithelial Junctional Cytoskeleton · correlation 0.72
- Lysosomal Proteolysis ECM · correlation 0.71
- Integrin Adhesion Signaling · correlation 0.71
- Complement Immune Evasion · correlation 0.71
- Epithelial Cell Junctions · correlation 0.71
- Lysosomal Autophagy Membrane · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.