mDC Inflammatory Activation
Gene co-expression module in Dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
This core-coherence module is tightly enriched in mDC with strong fold-changes. Hub genes include KDM2B (histone demethylase, epigenetic regulator), TRAFD1 (negative regulator of innate immune/TLR signaling), TBC1D4 and TBC1D8 (RAB-GAPs involved in vesicular trafficking/endosomal sorting), RAB5B (early endosome GTPase), RASSF4 (RAS-association domain, apoptosis/signaling), POGLUT1 (O-glucosyltransferase, Notch pathway), IL15 (cytokine promoting NK/T-cell survival), and CD84 (SLAM family receptor). The module is significantly upregulated in inflammation (especially CD) and downregulated with treatment. The combination of TRAFD1 (innate immune brake), IL15 (inflammatory cytokine), TBC1D4/TBC1D8/RAB5B (endosomal trafficking), and KDM2B (epigenetic regulation) in mDC suggests a program of mDC-specific inflammatory activation with endosomal regulation. TRAFD1 and IL15 are particularly linked to innate immune activation states. The strong inflammation delta and mDC specificity point to an inflammatory mDC activation state. Neighbor modules (M160, M27, M13) are also mDC-enriched, supporting a cluster of mDC-specific programs.
Genes
Most correlated modules
- Immature DC Metabolism · correlation 0.96
- Tolerogenic mDC · correlation 0.96
- Death Receptor Signaling · correlation 0.95
- DC Maturation Migration · correlation 0.95
- Non-canonical NF-κB · correlation 0.95
- mTOR Nutrient Sensing · correlation 0.94
- Lysosomal Trafficking Regulation · correlation 0.91
- MHC-I Antigen Presentation · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.