Non-canonical NF-κB
Gene co-expression module in Dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
This module is enriched in mDC/cDC1 and contains MAP3K14 (NIK, the master kinase of the non-canonical NF-κB pathway), RELB's upstream activator context, HIVEP1 (NF-κB binding transcription factor), MAML2 (Notch co-activator), BTG1 (anti-proliferative/differentiation factor), STK4 (MST1, Hippo/apoptosis kinase), ORAI1 (calcium channel for NFAT activation), CYTH1 (ARF GEF involved in DC activation), ZBTB10 (transcriptional repressor), and RNF144B (E3 ubiquitin ligase). MAP3K14/NIK is the defining hub of non-canonical NF-κB signaling. The module shows modest inflammation association and is a neighbor of M68 (canonical NF-κB/maturation). Together they represent canonical vs. non-canonical NF-κB arms in DC activation. This module specifically reflects non-canonical NF-κB pathway activation in mDCs.
Genes
Most correlated modules
- DC Maturation Migration · correlation 0.96
- mDC Inflammatory Activation · correlation 0.95
- TNF/NF-κB DC Activation · correlation 0.93
- Death Receptor Signaling · correlation 0.92
- Tolerogenic mDC · correlation 0.91
- Lysosomal Trafficking Regulation · correlation 0.91
- mTOR Nutrient Sensing · correlation 0.90
- MHC-I Antigen Presentation · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.