Death Receptor Signaling
Gene co-expression module in Dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 19 genes have a known function matching the annotation |
Why this annotation
This strong-coherence module is enriched in mDC with notable upregulation in inflammation. Hub genes include FAS (CD95, apoptosis receptor, also involved in DC activation/tolerance), TNFRSF9 (4-1BB/CD137, co-stimulatory TNFR family member, highly enriched 24.7x in mDC), CASP7 (executioner caspase, apoptosis), FOXP1 (transcription factor, DC differentiation), DERL1 (ER-associated degradation), GSN (gelsolin, actin remodeling), ATOX1 (copper chaperone), RCN1 (ER calcium binding), SBNO2 (anti-inflammatory transcriptional regulator). The combination of FAS, TNFRSF9, and CASP7 strongly suggests apoptosis/cell death signaling. TNFRSF9 (4-1BB) is a co-stimulatory molecule expressed on activated DCs. FOXP1 regulates DC differentiation. The inflammation upregulation and apoptotic machinery suggest this is an mDC activation-induced apoptosis/death receptor signaling program. Neighbor modules are also mDC-enriched, consistent with this being part of an mDC activation cluster.
Genes
Most correlated modules
- mDC Inflammatory Activation · correlation 0.95
- mTOR Nutrient Sensing · correlation 0.95
- DC Maturation Migration · correlation 0.94
- Non-canonical NF-κB · correlation 0.92
- Lysosomal Trafficking Regulation · correlation 0.92
- Tolerogenic mDC · correlation 0.92
- Immature DC Metabolism · correlation 0.91
- TNF/NF-κB DC Activation · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.