DC Maturation Migration
Gene co-expression module in Dendritic cells
| Category | Migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 18 genes have a known function matching the annotation |
Why this annotation
This module is dominated by canonical mature/migratory DC markers: LAMP3 (54.6x mDC enrichment, a hallmark of mature migratory DCs), CCR7 (50.1x, the chemokine receptor driving DC migration to lymph nodes), FSCN1 (28.8x, actin-bundling protein upregulated in mature DCs), MARCKSL1 and MARCKS (actin/membrane dynamics in DC maturation), RELB and TRAF1/BIRC3 (NF-κB pathway activation downstream of maturation signals), RAB9A and SYNGR2 (vesicular trafficking in mature DCs), and RFTN1 (lipid raft organization). The module is strongly upregulated in inflammation (delta_inflammation=0.617) and decreases with treatment, consistent with inflammatory DC maturation. All genes are core members with extreme mDC enrichment. This is a tight, coherent program of DC maturation and lymph node migration.
Genes
Most correlated modules
- Non-canonical NF-κB · correlation 0.96
- Tolerogenic mDC · correlation 0.95
- mDC Inflammatory Activation · correlation 0.95
- Death Receptor Signaling · correlation 0.94
- MHC-I Antigen Presentation · correlation 0.94
- Cytokine-responsive mDC · correlation 0.94
- TNF/NF-κB DC Activation · correlation 0.92
- mTOR Nutrient Sensing · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.