TNF/NF-κB DC Activation
Gene co-expression module in Dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 20 genes have a known function matching the annotation |
Why this annotation
This module contains a coherent set of NF-κB/TNF-response and DC activation genes: CFLAR (c-FLIP, anti-apoptotic NF-κB target), TNFAIP2 (TNF-alpha-induced protein 2), TANK (TRAF-associated NF-κB activator), CD40 (co-stimulatory receptor, NF-κB activator in DCs), IRF4 (DC differentiation/activation transcription factor), IRF1 (interferon regulatory factor), CDKN1A (p21, cell cycle arrest/stress response), DUSP5 (MAPK phosphatase, negative feedback), GADD45A (DNA damage/stress response), SOCS1 (negative regulator of JAK-STAT), BCL2L11 (BIM, apoptosis), CSF2RA (GM-CSF receptor alpha), GPR132 (proton-sensing GPCR, inflammation), GLS (glutaminase, metabolic reprogramming). The module reflects TNF/NF-κB-driven DC activation with concurrent anti-apoptotic and negative feedback programs. It is a neighbor of M68 (maturation) and M138 (tolerogenic), representing the inflammatory cytokine response arm. The uniform expression and mDC enrichment are consistent with a broadly activated DC state.
Genes
Most correlated modules
- Non-canonical NF-κB · correlation 0.93
- DC Maturation Migration · correlation 0.92
- mDC Tolerogenic Identity · correlation 0.90
- Death Receptor Signaling · correlation 0.89
- Cytokine-responsive mDC · correlation 0.88
- MHC-I Antigen Presentation · correlation 0.87
- Tolerogenic mDC Activation · correlation 0.86
- mDC Inflammatory Activation · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.