Tolerogenic mDC
Gene co-expression module in Dendritic cells
| Category | Tolerance |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 18 genes have a known function matching the annotation |
Why this annotation
This module contains the most defining genes of tolerogenic/regulatory mature DCs: CCL19 (265x mDC — lymph node homing chemokine, co-expressed with CCR7 in mature DCs), CCL22 (59x mDC — Treg-attracting chemokine, hallmark of tolerogenic DCs), SOCS2 (45x mDC — negative regulator of cytokine signaling, promotes tolerogenic DC function), NRP2 (44x mDC — neuropilin-2, marker of tolerogenic/regulatory DCs), CD200 (27x mDC — immunosuppressive ligand), EBI3 (71x mDC — subunit of IL-27 and IL-35, immunosuppressive cytokines), TMEM176B (immature/tolerogenic DC marker), CERS6 (ceramide synthase, lipid metabolism in DC function), MGLL (monoglyceride lipase, endocannabinoid/lipid signaling), TRIP10 (CDC42-interacting, actin dynamics), SWAP70 (Rac GEF, phagocytosis/migration). The combination of CCL22, CD200, SOCS2, NRP2, and EBI3 is a strong tolerogenic DC signature. This module is a neighbor of M68 (maturation/migration) and M149 (MHC-I presentation), representing the tolerogenic arm of mature mDC biology. Upregulated in CD inflammation, possibly reflecting a regulatory counter-response.
Genes
Most correlated modules
- mDC Inflammatory Activation · correlation 0.96
- DC Maturation Migration · correlation 0.95
- mTOR Nutrient Sensing · correlation 0.94
- Immature DC Metabolism · correlation 0.94
- Death Receptor Signaling · correlation 0.92
- Cytokine-responsive mDC · correlation 0.92
- Non-canonical NF-κB · correlation 0.91
- MHC-I Antigen Presentation · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.