Actin Cytoskeletal Remodeling
Gene co-expression module in Dendritic cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include RHOQ (Rho GTPase, vesicular trafficking/actin), JMY (junction-mediating protein, actin nucleation via Arp2/3), BAIAP2 (IRSp53, actin/membrane protrusion), CCND2 (cyclin D2, G1/S cell cycle), REV3L (DNA polymerase zeta, DNA damage repair), ATG2A (autophagy), ITPR1 (IP3 receptor, calcium), MAFG (small Maf transcription factor), NCR3LG1 (NK ligand). The actin nucleation triad (RHOQ/JMY/BAIAP2) is the strongest signal, pointing to cytoskeletal remodeling. CCND2 and REV3L suggest some proliferative/DNA repair context. Neighbor context with M141 and M26 supports an activation-associated cytoskeletal program.
Genes
Most correlated modules
- NRF2 Metabolic Stress · correlation 0.89
- MMP9 Effector cDC2 · correlation 0.89
- AP-1 cDC2 Activation · correlation 0.89
- RNA Splicing Processing · correlation 0.88
- Tolerogenic Lipid Metabolism · correlation 0.88
- DC Metabolic Activation · correlation 0.87
- DC Proliferation Program · correlation 0.87
- OLR1+ cDC2 Subset · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.