Tolerogenic Lipid Metabolism
Gene co-expression module in Dendritic cells
| Category | Tolerance |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include RCOR1 (CoREST transcriptional corepressor), CLN8 (ER membrane protein involved in lipid metabolism/ceroid lipofuscinosis), ENTPD1 (CD39, ectonucleotidase that hydrolyzes ATP to adenosine — key tolerogenic marker on DCs), GPAT3 (glycerophospholipid synthesis), LPIN1 (phosphatidic acid phosphatase, lipid metabolism), GNA13 (G-protein alpha 13), GPR65 (proton-sensing GPCR), GLA (lysosomal alpha-galactosidase), and FNIP2 (FLCN-interacting protein, mTOR/AMPK). The combination of ENTPD1/CD39 (tolerance), RCOR1 (transcriptional repression), and lipid metabolic genes suggests a tolerogenic/regulatory DC lipid-metabolic program. Broadly expressed across DC subsets.
Genes
Most correlated modules
- DC Metabolic Activation · correlation 0.89
- MMP9 Effector cDC2 · correlation 0.88
- Actin Cytoskeletal Remodeling · correlation 0.88
- AP-1 cDC2 Activation · correlation 0.87
- Golgi-Endosomal Trafficking · correlation 0.85
- p53 Transcriptional Regulation · correlation 0.85
- Glucocorticoid Stress Response · correlation 0.82
- OLR1+ cDC2 Subset · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.