Cytokine-responsive mDC
Gene co-expression module in Dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 18 genes have a known function matching the annotation |
Why this annotation
This module contains CCL17 (16.8x mDC — Th2-attracting chemokine, produced by mature DCs), BATF (AP-1 transcription factor critical for DC and T-cell differentiation), STAT5A (JAK-STAT signaling, cytokine response), BCL2L1 (anti-apoptotic, survival), IFNGR2 (IFN-gamma receptor), SEMA7A (semaphorin, immune cell migration/activation), RAMP1 (CGRP receptor component, neuroimmune signaling), GPR171 (neuropeptide receptor), RAPGEF2 (Rap GEF, integrin signaling/migration), MAP3K13 and MAP4K4 (MAPK kinases), RHOH (Rho GTPase, lymphocyte signaling), UGCG (glucosylceramide synthase, lipid metabolism), ZBTB38 (transcriptional repressor), NECAP2 (endocytosis), VOPP1 (vesicular trafficking), N4BP2L1 (ubiquitin binding), TFG (TRK-fused gene, secretory pathway). CCL17 and BATF together with STAT5A and IFNGR2 suggest a cytokine-driven DC activation state with Th2-polarizing output. The neuroimmune components (RAMP1, GPR171) and SEMA7A suggest this module also captures DC responses to neuropeptide signals in the gut. The inflammation upregulation and mDC enrichment are consistent. This is best labeled as a cytokine-responsive DC state with Th2 polarization capacity.
Genes
Most correlated modules
- DC Maturation Migration · correlation 0.94
- MHC-I Antigen Presentation · correlation 0.93
- Tolerogenic mDC · correlation 0.92
- Tolerogenic mDC Activation · correlation 0.88
- Non-canonical NF-κB · correlation 0.88
- mTOR Nutrient Sensing · correlation 0.88
- TNF/NF-κB DC Activation · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.