Spliceosome RNA Processing
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 33 genes have a known function matching the annotation |
Why this annotation
Hub genes include LSM5, LSM4, LSM3 (Sm-like RNA splicing factors), SNRPD2 (snRNP component), HMGB1 (chromatin/nuclear factor enriched in proliferating cells), ANAPC11 (APC/C ubiquitin ligase subunit, cell cycle), NUDT1 (nucleotide sanitization, elevated in S-phase), MZT2B (microtubule nucleation), ANP32B (chromatin regulation), PPIH (spliceosome cyclophilin). Most genes are enriched in prolif_DC subset (2-5x). NDUFS6, NDUFC2, UQCRH, ECHS1 are mitochondrial/metabolic genes that co-express with the proliferation program. The dominant theme is pre-mRNA splicing machinery co-expressed with cell cycle regulators in proliferating DCs. Neighbor context: M23 and M14 are also enriched in prolif_DC and housekeeping/metabolic programs, consistent with a proliferation-associated neighborhood. The spliceosome/RNA processing component is the most specific label here.
Genes
Most correlated modules
- Mitochondrial OxPhos · correlation 0.96
- DC Proliferation · correlation 0.96
- Mitotic Proliferation · correlation 0.95
- Mitochondrial OxPhos · correlation 0.95
- Nucleotide Biosynthesis · correlation 0.94
- Endocytic Vesicular Trafficking · correlation 0.93
- Metabolic Housekeeping · correlation 0.92
- Complex I Assembly · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.