Mitochondrial Metabolism UCP2
Gene co-expression module in Dendritic cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 18 genes have a known function matching the annotation |
Why this annotation
The top hub gene UCP2 (uncoupling protein 2) is a mitochondrial inner membrane protein that uncouples oxidative phosphorylation from ATP synthesis, regulating ROS production and metabolic state in immune cells. MRPL52 and MRPS5 are mitochondrial ribosomal proteins. TIMM8B is a mitochondrial import protein. IDH3B is a TCA cycle enzyme. COX14 is a cytochrome c oxidase assembly factor. GRPEL1 is a mitochondrial chaperone. These genes collectively define a mitochondrial metabolism/OxPhos program. Additional genes include HNRNPR (splicing, linking to the splicing neighborhood), MAGOH (mRNA splicing/export), RTF1 (transcription elongation), and LTB (lymphotoxin-B, inflammatory). The module is uniformly expressed across DC subsets with moderate coherence. The mitochondrial hub genes (UCP2, MRPL52, TIMM8B, IDH3B, MRPS5, COX14, GRPEL1) dominate and define the core program. UCP2 in DCs is known to regulate inflammatory vs. tolerogenic states. The neighbor context (splicing modules M45, M126, M44) explains the co-expression of splicing genes as a shared housekeeping co-regulation.
Genes
Most correlated modules
- RNA Splicing Processing · correlation 0.93
- Mitochondrial Biogenesis · correlation 0.91
- Mitochondrial OxPhos · correlation 0.90
- Proteostasis & Chaperones · correlation 0.90
- Mitochondrial DNA Repair · correlation 0.90
- hnRNP Splicing Program · correlation 0.89
- Ribosome Biogenesis · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.