DNA Replication Chromatin
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 21 genes have a known function matching the annotation |
Why this annotation
ORC6 (origin recognition complex subunit 6, 18.5x in prolif_DC) is the clearest anchor — it is essential for DNA replication initiation. SUPT16H (FACT complex, histone chaperone for replication), HAT1 (histone H4 acetyltransferase, newly synthesized histone processing), PSIP1 (LEDGF, chromatin tethering), NUDC (nuclear distribution, mitotic spindle), ATXN10 (cell cycle regulation), and LSM2 (RNA splicing during S-phase) all support a DNA replication and chromatin assembly program. This module is strongly coherent and tightly linked to the prolif_DC state, consistent with its neighbors M61 and M82.
Genes
Most correlated modules
- Endocytic Vesicular Trafficking · correlation 0.95
- Nucleotide Biosynthesis · correlation 0.95
- DC Proliferation · correlation 0.94
- Mitotic Proliferation · correlation 0.93
- Metabolic Housekeeping · correlation 0.93
- Metabolic Housekeeping · correlation 0.93
- RNA Splicing Processing · correlation 0.92
- Complex I Assembly · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.