DC Proliferation
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes HMGN1, ERH, RAN, SNRPD1, SNRPE, CBX3, RUVBL1, BANF1 are all strongly associated with cell cycle progression, nuclear organization, and DNA replication. LDHB and MPC2 reflect metabolic reprogramming in proliferating cells. Nearly all genes show 2-3x enrichment in prolif_DC subset, confirming this is a proliferating DC program. CCT2 (chaperonin), SRP9 (signal recognition), and CACYBP (ubiquitin-related) support active protein synthesis and turnover in dividing cells. VDAC3 and NDUFV1 reflect mitochondrial activity supporting proliferation. Module coherence is strong, consistent with a tight proliferation program.
Genes
Most correlated modules
- Nucleotide Biosynthesis · correlation 0.97
- Spliceosome RNA Processing · correlation 0.96
- DNA Replication Chromatin · correlation 0.94
- Mitotic Proliferation · correlation 0.94
- Complex I Assembly · correlation 0.93
- Endocytic Vesicular Trafficking · correlation 0.93
- Metabolic Housekeeping · correlation 0.92
- Mitochondrial OxPhos · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.