RNA Splicing Processing
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
Top hub XRCC5 (Ku80) is a key DNA double-strand break repair protein. HNRNPF, HNRNPK, SRRM1, SRSF3, NONO are RNA splicing/processing factors. SET is a chromatin regulator and PP2A inhibitor involved in DNA repair signaling. E2F3 is a cell cycle transcription factor, KRR1 is involved in ribosome biogenesis and cell cycle. CCT3 is a chaperonin. The module is moderately coherent with several weak-membership hub genes, suggesting a mixed RNA processing and DNA repair/cell cycle program. Neighbor context with M121 (prolif_DC) supports a cell cycle-adjacent program, but the dominant theme is nuclear RNA processing and DNA repair rather than pure proliferation. mDC enrichment (5.1x) distinguishes this from the prolif_DC-dominant M121.
Genes
Most correlated modules
- RNA Splicing Processing · correlation 0.94
- DNA Replication Chromatin · correlation 0.92
- Proteostasis & Chaperones · correlation 0.91
- Endocytic Vesicular Trafficking · correlation 0.91
- Mitotic Proliferation · correlation 0.90
- Nucleotide Biosynthesis · correlation 0.88
- Metabolic Housekeeping · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.