Endocytic Vesicular Trafficking
Gene co-expression module in Dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 37 genes have a known function matching the annotation |
Why this annotation
AP2M1 (clathrin adaptor mu2 subunit, endocytosis), FUCA2 (lysosomal alpha-fucosidase), ITGAE (CD103/integrin alphaE, gut-homing DC marker), HLTF (E3 ubiquitin ligase/DNA damage), COPS5 (COP9 signalosome, ubiquitin pathway), TRAPPC4 (vesicle trafficking), and NUCB2 (calcium-regulated secretion) together suggest a DC endocytic/vesicular trafficking program. ITGAE/CD103 marks gut-resident cDC1s. AP2M1 and TRAPPC4 are canonical endocytic/vesicular trafficking components. SAC3D1 and CXXC1 add a proliferation flavor consistent with the prolif_DC neighborhood. The dominant functional theme is endocytosis and vesicular trafficking in gut DCs.
Genes
Most correlated modules
- Metabolic Housekeeping · correlation 0.95
- DNA Replication Chromatin · correlation 0.95
- MYC-driven Proliferation · correlation 0.94
- Mitotic Proliferation · correlation 0.94
- Mitochondrial OxPhos · correlation 0.93
- DC Proliferation · correlation 0.93
- Spliceosome RNA Processing · correlation 0.93
- Metabolic Housekeeping · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.