Serotonergic EC specification
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 16 genes have a known function matching the annotation |
Why this annotation
The module pairs FEV, the serotonergic transcription factor, with GCH1 and QDPR, which make and recycle the BH4 cofactor that TPH1 needs, alongside NEUROD1, PCSK1 and CRYBA2 of the neuroendocrine secretory program. Enrichment is modest (~2x) and several genes are pan-EEC, so part of the signal may reflect general EEC maturation.
Genes
Most correlated modules
- LMX1A/VMAT1 EC identity · correlation 0.80
- Serotonin biosynthesis · correlation 0.76
- GULP1/PRDM16 EC genes · correlation 0.71
- CALCR/CDHR3 EC program · correlation 0.68
- SCN3A/HCN1 EC excitability · correlation 0.62
- CES1/TRPC7 EC subset · correlation 0.57
- RASGRP1/MME K-cell signaling · correlation 0.56
- TRPA1/ADH4 chemosensory EC · correlation 0.52
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.