CES1/TRPC7 EC subset
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
The core hub genes CES1, TRPC7, TMEFF2, ROS1, OVCH1 and PLAAT1 are highly concentrated in EC cells (7–23x) but detected in only a fraction of them, which points to a distinct EC subpopulation rather than the pan-EC serotonin machinery. CHRM3 (muscarinic drive of serotonin release) and TRPC7 suggest a receptor-rich sensory EC subtype.
Genes
Most correlated modules
- RASGRP1/MME K-cell signaling · correlation 0.82
- TAC1/RPRML small-bowel EEC · correlation 0.77
- Proximal regional identity · correlation 0.68
- Small-intestinal nutrient metabolism · correlation 0.64
- SCN3A/HCN1 EC excitability · correlation 0.60
- EC Neuronal Excitability · correlation 0.59
- TRPA1/ADH4 chemosensory EC · correlation 0.58
- Serotonergic EC specification · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.