Neurotensin N-cell Program
Gene co-expression module in Enteroendocrine cells
| Category | n cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 4 of 16 genes have a known function matching the annotation |
Why this annotation
The hub genes NTS and GHRH, along with MSMB and RASSF9, are concentrated 10–20x in N and I cells, defining the distal neurotensin-secreting N-cell identity. The absorptive-epithelium genes (CEACAM6, HMGCS2, UGT2B17, LYPD8) are localized to the same subsets rather than spread, so they reflect the distal regional state of these cells rather than contamination.
Genes
Most correlated modules
- RARRES1/PCSK5 small-bowel program · correlation 0.83
- NPW terminal maturation · correlation 0.80
- Small-intestinal absorptive signature · correlation 0.76
- Small-intestinal Nutrient Sensing · correlation 0.73
- Small-intestinal I/K-cell signature · correlation 0.69
- N/K villus program · correlation 0.68
- INSL5/N-cell epithelial state · correlation 0.67
- Peptidergic Secretory Granule · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.