Small-intestinal I/K-cell signature
Gene co-expression module in Enteroendocrine cells
| Category | I cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
The module is localized to small-intestinal EEC subsets, strongest in I and K cells, led by GSG1L (I 14.2x, K 8.0x), ITPR1 and ABCB10/GSTK1. HLA-DRB1/DRB5 are localized to these subsets, consistent with epithelial MHC-II expression typical of small intestine rather than DC contamination; HLA-DRB5 is haplotype-dependent, so donor effects may contribute.
Genes
Most correlated modules
- RARRES1/PCSK5 small-bowel program · correlation 0.90
- CDX2/HNF4G intestinal identity · correlation 0.88
- Small-intestinal absorptive signature · correlation 0.84
- Small-intestinal nutrient metabolism · correlation 0.82
- Small-intestinal Nutrient Sensing · correlation 0.74
- Villus enterocyte-like state · correlation 0.69
- Small-intestinal lipid metabolism · correlation 0.69
- Neurotensin N-cell Program · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.